I'm a huge fan of Jane McGonigal, the game designer, researcher and author from the Institute of the Future. She's been called the public face of gamification and evangelizes improving the quality of human life and social ills through game mechanics. Her TED Talk on Gaming Can Make A Better World is by far one of the best TED talks I've heard. In 2009, she suffered a traumatic brain injury and had difficulties recovering from it. Jane decided to create a game, SuperBetter to help her recover. This has now been released as a platform SuperBetter that helps people suffering from any aliments, from obesity to a broken leg to addiction through pervasive game play. Here's a video of her talking about Super Better:
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